The Barrier Highway is closed in both directions at Bindarrah, near the SA and NSW border, after an horrific collision involving a truck and a freight train.
The accident happened around 10.30am.
Police have said motorists coming from New South Wales would not be able to travel past Broken Hill on the Barrier Highway into South Australia and motorists travelling east will not be able to travel past Petersburg Road – Peterborough turnoff.
It is expected to be some time before the road is open.